Anatomy

Neuroendocrine Cells and Peptidergic Innervation in Human by Luis Santamaria, Ildefonso Ingelmo, Lucía Alonso, José

By Luis Santamaria, Ildefonso Ingelmo, Lucía Alonso, José Manuel Pozuelo, Rosario Rodríguez

The prostate hosts an enormous volume of neuroendocrine cells which starting place and practical position have to be higher addressed. those cells synthesize and bring a couple of neurosecretory elements (serotonin, neuropeptides) having regulative actions over progress, phone differentiation, and secretion and can have a extraordinary effect within the improvement of prostatic proliferative problems corresponding to hyperplasia or melanoma. in addition, the self sufficient apprehensive process seems correct within the upkeep of structural and sensible integrity of the prostate, a large choice of peptidergic fibres has been defined within the prostate gland; resembling neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), substance P (SP), calcitonin gene-related peptide (CGRP) nerves, and so on. there's facts approximately morphologic and useful relationships among neuroendocrine cells and prostate nerve fibres, leading to a neuro-hormonal approach that would modulate the androgenic motion at the prostate.

Using immunohistochemistry and stereologic quantification, the authors of the current learn care for the demonstration that the neuroendocrine cells inhabitants from transition sector of the human prostate used to be more than in either imperative and peripheral areas, and this is installed relation to the genesis of BPH. in addition, they saw that the neuroendocrine cells and the peptidergic innervation of rat prostate may be encouraged via getting older and androgenic prestige. different components, as pharmacological castration, or prolactin motion, may be additionally modulate the neuroendocrine-peptidergic system.

Show description

Read or Download Neuroendocrine Cells and Peptidergic Innervation in Human and Rat Prostrate PDF

Similar anatomy books

Neuroendocrine Cells and Peptidergic Innervation in Human and Rat Prostrate

The prostate hosts an enormous quantity of neuroendocrine cells which starting place and useful function must be higher addressed. those cells synthesize and convey a couple of neurosecretory elements (serotonin, neuropeptides) having regulative actions over development, telephone differentiation, and secretion and may have a impressive effect within the improvement of prostatic proliferative problems comparable to hyperplasia or melanoma.

Biology in Physics: Is Life Matter? (Polymers, Interfaces and Biomaterials)

Biology in Physics is a thorough new ebook which bridges the distance among biology and physics. the purpose is to advertise an interdisciplinary alternate of medical info and concepts, to be able to stimulate cooperation in study. The scope of this quantity explores either the suggestions and strategies of biophysics and illustrates the most recent advances in our figuring out of a few of the particular mechanisms which are utilized by dwelling organisms.

Glutamate and gaba receptors and transporters: structure, function and pharmacology

The ever present presence of glutamate and GABA receptors within the anxious procedure makes those receptor structures pivotal to our knowing of neurotransmission. Cloning of the molecular parts of those receptor platforms has supplied insights to the selectivity of many medicinal drugs and particular characterisation on the molecular point is rising.

Biology of Sensory Systems, Second Edition

Because book of the 1st variation, large advancements have taken position in sensory biology examine and new insights were supplied specifically through molecular biology. those convey the similarities within the molecular structure and within the body structure of sensory cells throughout species and throughout sensory modality and sometimes point out a standard ancestry relationship again over part one thousand million years.

Extra info for Neuroendocrine Cells and Peptidergic Innervation in Human and Rat Prostrate

Example text

1994a); therefore the chromogranins are useful as a marker for these cells in both normal and pathologic glands (Abrahamsson 24 The Neuroendocrine System and the Human Prostate et al. 1989; Theodoropoulos et al. 2005). Although the three chromogranins are expressed in the normal prostate and in nodular hyperplasia (Schmid et al. 1994), chromogranin A is more frequently identified (Gkonos et al. 1995a). In cases of carcinoma with neuroendocrine differentiation, the predominant type was chromogranin B (Schmid et al.

A Numerical density (N V ) of neuroendocrine cells immunostained by serotonin, expressed in number of immunoreactive cells x 103 /mm3 of epithelial tissue from prepubertal (PP), pubertal (P), young adult (YA), and aged adult (AA) rats. b Absolute number of neuroendocrine cells immunostained to serotonin expressed in number of immunoreactive cells per 103 from prepubertal (PP), pubertal (P), young adult (YA), and aged adult (AA) rats. 05) These results differ from those described in human prostate by some authors (Cohen et al.

1986). At this moment the blood levels of testosterone are low, and the increase in prostatic weight is moderated. In puberty, the level of androgens (testosterone) increases significantly and both prostate weight and prostatic DNA content also increase Macroscopic Description of the Rat Prostate 39 rapidly (Donjacour and Cunha 1988). By contrast, the morphogenesis of the human prostate occurs entirely during the fetal period, with ductal development occurring during the first half of pregnancy (Xue et al.

Download PDF sample

Rated 4.85 of 5 – based on 7 votes