Anatomy

Glutamate and gaba receptors and transporters: structure, by Jan Egebjerg, Arne Schousboe, Povl Krogsgaard-Larsen

By Jan Egebjerg, Arne Schousboe, Povl Krogsgaard-Larsen

The ever present presence of glutamate and GABA receptors within the worried method makes those receptor platforms pivotal to our knowing of neurotransmission. Cloning of the molecular elements of those receptor structures has supplied insights to the selectivity of many medicines and certain characterisation on the molecular point is rising. in addition, non-stop improvement of novel and selective medications has printed distinct info at the mechanism of receptor activation and legislation. in spite of the fact that, the quick improvement of other features of glutamate and GABA receptor examine makes it more and more tricky to set up a common view of the sector. reports of the receptors are a multi-disciplinary job using many specialized recommendations. This publication conveys contemporary discoveries in a framework of the fundamental thoughts within the box of glutamate and GABA receptor examine. Glutamate and GABA Receptors and Transporters: constitution, functionality and Pharmacology is acceptable for postgraduate scholars learning ligand gated channels but in addition precious for business and educational study scientists in either the glutamate and GABA box. Universities delivering courses in neuroscience, molecular pharmacology or medicinal chemistry will locate this a precious reference.

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Glutamate and gaba receptors and transporters: structure, function and pharmacology

The ever-present presence of glutamate and GABA receptors within the anxious method makes those receptor platforms pivotal to our knowing of neurotransmission. Cloning of the molecular parts of those receptor platforms has supplied insights to the selectivity of many medicinal drugs and distinct characterisation on the molecular point is rising.

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1996) ‘Subtypeselective inhibition of N-methyl-D-aspartate receptors by haloperidol’, Mol. Pharm. 50: 1541–1550. , Masu, M. and Nakanishi, S. (1993) ‘Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits’, J. Biol. Chem. 268: 2836–2843. , Mishina, M. and Sugiyana, H. (1997) ‘Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor ⑀1 or ⑀2 subunit’, J. Physiol. 500: 401–408. E. F. (1987) ‘Glutamate activates multiple single channel conductances in hippocampal neurons’, Nature 325: 522–525.

19: 8281–8291. 32 Stuart G. G. ’, Current Biology 5: 841–843. G. and Farrant, M. (2001) ‘NMDA receptor subunits: diversity, development and disease’, Current Opinions in Neurobiology (in press). G. C. (1985) ‘Ion channels activated by L-glutamate and GABA in cultured cerebellar neurons of the rat’, Proc. R. Soc. Lond. B. 224: 367–373. G. M. (1987) ‘Multiple conductance channels activated by excitatory amino acids in cerebellar neurons’, Nature 325: 525–528. , Farrant M. and Feldmeyer D. (1995) ‘NMDA channel conductance: a user’s guide’, in H.

Thus a small shift in pH, above or below the normal level, has a dramatic effect on the size of the NMDARcurrent. This inhibition arises mainly through a reduction in the frequency of channel openings, without a decrease in the channel conductance. , 1990; see Chesler and Kaila, 1992). This sensitivity to the ambient level of protons is thought to be important during ischaemia and seizures as these conditions are accompanied by acidification of the extracellular medium (Chesler and Kaila, 1992), an effect that could be heightened in the narrow confines of the synaptic cleft (see Traynelis and Cull-Candy, 1991, for discussion).

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