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Extra info for Current Topics in Microbiology and Immunology: Ergebnisse der Mikrobiologie und Immunitatsforschung
Of the nonsense suppressors known in S. pombe, only the ochre-amber suppressors of class I cause a measurable increase of the generation time of strains grown in an enriched yeast extract-glucose medium (M. MINET, and P. THURIAUX, unpublished). In stock cultures, however, both the ochre-amber suppressors of the first class (SUP1-oa and SUP2-oa) and the amber-specific suppressors of the third class (SUP3-a and SUP8-a) show adverse effects. Both classes of suppressors cause a selective pressure in favour of mutants which have lost suppressor activity, either because of secondary mutations in the suppressor locus or because of mutations in modifier loci.
However, with strains carrying either sin2, sin3 or sin14, the generation time is approximately doubled. The fourteen antisuppressors of S. pombe have been analyzed for the suppressor specificity of their modifying action, using growth on minimal medium of suppressor sensitive adenine mutants carrying both a suppressor and an antisuppressor as a criterion to distinguish between active and inactive combinations (HOFER, 1969; M. MINET and P. ) One of the modifiers which were tested in combination with ochre-specific suppressors has been found to differentiate between SUP3-o+SUP9-o on the one hand and SUP8-o+SUP10-o on the other hand: modifier sin1 which was isolated on the background of the ochre suppressor SUP9-o (HOFER, 1969), shows an antisuppressor activity in combination with SUP3-o and SUP9-o but not with SUP8-o and SUP10-o.
Yeasts also differ from E. coli in having a greater redundancy of the tRNA genes. From DNA-RNA hybridization experiments, SCHWEIZER et al. (1969) estimate the presence of 320 to 400 tRNA genes in the genome of S. serevisiae. The selection of nonsense suppressors in Saccharomyces has provided evidence for a redundancy as high as 8 for the tyrosyl tRNA genes. Yet there is a unique species, either a tryptophan or a glutamine tRNA gene, giving rise to the suppressor in Class XI. Unless there is a differential regulation of the transcription of the various tRNA genes, the state of redundancy of each species must, through evolution, in some measure reflect the occurrence of the corresponding amino acid in the proteins.