By Jacques Ferlay, Clarisse Héry, Philippe Autier (auth.), Christopher Li (eds.)
As the commonest melanoma clinically determined between girls world-wide, breast melanoma is a sickness of substantial public health and wellbeing significance. The variety of demonstrated and hypothesized danger elements for breast melanoma exceeds that of the other melanoma leading to a wealthy, yet advanced and sometimes conflicting literature at the epidemiology of this illness. Our knowing of things that give a contribution to breast melanoma danger, in addition to the biology and molecular foundation for this universal disorder, has vastly elevated during the last few a long time. This publication offers a accomplished overview and significant evaluation of the epidemiology literature on all significant elements of breast melanoma occurrence and mortality, etiology, and results. Chapters are written by means of across the world famous leaders within the box and supply a well timed overview of conventional etiologic chance components, in addition to extra lately evaluated exposures. a number of chapters also are dedicated to scientific features of breast melanoma together with screening, prognosis and therapy, and survival. hence, this can be the main up to date and accomplished e-book on breast melanoma epidemiology available.
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Additional info for Breast Cancer Epidemiology
2000) tend to be of higher grade relative to breast cancers in older, postmenopausal women: <4% of low-grade but >9% of high-grade breast cancers are diagnosed in women aged <40 years (Anderson et al. 2007a). Additionally, in the United States, breast cancers diagnosed in non-Hispanic white women tend to be of lower grade, on average, than breast cancers diagnosed in women of other racial/ethnic groups (Li et al. 2003). Familial breast cancers also tend to be of higher grade relative to sporadic breast cancers (Marcus et al.
Clin Cancer Res 13:2329–2334 Carson W, Sanchez-Forgach E, Stomper P, Penetrante R, Tsangaris TN, Edge SB (1994) Lobular carcinoma in situ: observation without surgery as an appropriate therapy. Ann Surg Oncol 1:141–146 Chung M, Chang HR, Bland KI, Wanebo HJ (1996) Younger women with breast carcinoma have a poorer prognosis than older women. Cancer 77:97–103 Claus EB, Risch NJ, Thompson WD (1990) Age at onset as an indicator of familial risk of breast cancer. Am J Epidemiol 131:961–972 Clavel-Chapelon F, the E3N-EPIC Group (2002) Differential effects of reproductive factors on the risk of pre- and postmenopausal breast cancer: results from a large cohort of French women.
Familial breast cancers also tend to be of higher grade relative to sporadic breast cancers (Marcus et al. 1996; Breast Cancer Linkage Consortium 1997; Lakhani et al. 2000; Palacios et al. 2005). Specifically, BRCA1-associated breast cancers demonstrate significantly greater pleomorphism and higher mitotic count than sporadic tumors and BRCA2-associated tumors are characterized by significantly lower tubule formation than sporadic tumors (Breast Cancer Linkage Consortium 1997; Lakhani et al. 2000).